![]() In short, the 3T scan and stereotactic 1.5T scan were co-registered with SurgiPlan (Elekta AB, Stockholm, Sweden) to enable planning in the stereotactic space. KeywordsĪbbreviations: ATR ( anterior thalamic radiation), CBT ( cognitive-behavioral therapy), CSTC ( cortico-striatal-thalamo-cortical), DBS ( deep brain stimulation), DWI ( diffusion-weighted MRI), MDD ( major depressive disorder), MFB ( (supero-lateral branch of the) medial forebrain bundle), NAc ( nucleus accumbens), OCD ( obsessive-compulsive disorder), PFC ( prefrontal cortex), SSRI ( selective serotonin reuptake inhibitor), TRD ( treatment-resistant depression), Y-BOCS ( Yale-Brown obsessive-compulsive scale), vALIC ( ventral anterior limb of the interior capsule), VC ( ventral capsule), VS ( ventral striatum), VTA ( ventral tegmental area), WM ( white matter) Prospective investigation is necessary to validate the clinical use of MFB targeting. These findings suggest that vALIC DBS for OCD may benefit from MFB-specific implantation and highlight the importance of corticolimbic connections in OCD response to DBS. ![]()
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